The Trump administration is poised to impose steep tariffs starting Wednesday on countries that import oil from Venezuela, in a move analysts said is unprecedented and will significantly increase global trade uncertainty.

Any country that buys oil from Venezuela will face 25% “secondary tariffs” on all of its trade with the United States, President Donald Trump said in a Truth Social post March 24. The levies go into effect April 2, Trump said in the post, though his executive order leaves the implementation to Secretary of State Marco Rubio’s discretion.

“If they buy their oil from Venezuela, they have to pay a 25% tariff to do business with the United States —that’s on top of existing tariffs,” Trump said during a March 24 press conference at the White House.

Trump’s secondary tariffs are “unprecedented and legally questionable, but that won’t prevent the administration from moving forward with them,” according to the consulting firm Rapidan Energy. The International Emergency Economic Powers Act has never been invoked to justify across-the-board tariffs against a country, according to Rapidan.

The tariffs will primarily affect China, the largest importer of Venezuela oil. India and Spain would also face levies unless the U.S. decides to grant exemptions for some countries. Rapidan expects importers to stop purchasing Venezuelan oil as they work to secure exemptions from the White House.

While the Europeans and Indians might get a reprieve, the U.S. has not exempted Chinese companies from sanctions in the past, according to Rapidan. Beijing will likely ditch Venezuelan barrels as a consequence, leading to a supply disruption of around 300,000 barrels per day.

Indeed, early signs suggest this could be happening. On Tuesday, Reuters reported that Venezuela’s exports of crude oil and fuel fell 11.5% in March, according to ship tracking data and documents.

Trump’s secondary tariffs have introduced a new wild card, Evercore ISI analyst Sarah Bianchi told clients in March 26 note.

The U.S. has imposed secondary sanctions in some cases on organizations doing business with blacklisted entities but it has not used trade tariffs in this way before, according to Bianchi.

Trump’s secondary tariffs could signal that he plans to significantly expand the use of tariffs beyond issues involving trade, the analyst wrote. In the case of Venezuela, the president is wielding them to pressure the Nicolas Maduro regime, which he alleges has sent Tren de Aragua gang members to the U.S.

“Adapting the idea of secondary sanctions to tariffs — and again using tariffs to achieve goals unrelated to trade — in our view further reduces the likelihood that April 2 is the peak of trade uncertainty,” Bianchi told clients.

She warned that Trump could be emboldened to use tariffs “to bolster the United States’ global leverage in advancing any number of other foreign policy objectives” if his crackdown on Venezuela is successful.